According to a study, use of zero-sugar foods and beverages such as yoghurt and diet soda may not be as beneficial to your health as previously thought because they can impede your liver’s ability to flush out toxins. artificial sweeteners
A team from the Medical College of Wisconsin in Wisconsin, United States, conducted a study on two sugar replacements known as nonnutritive sweeteners, which provide a sweet flavour with little or no calories. They were acesulfame potassium and sucralose, both of which are available in low-calorie forms.
These interfere with the activity of a protein that is critical in the detoxification of the liver as well as the metabolism of some medications.
A doctorate student at the Medical College of Georgia explained that many people are unaware that artificial sweeteners can be found in low- or no-sugar variants of yoghurts and snack meals, as well as in non-food products such as liquid medicines and some cosmetics.
The researchers discovered that the sweeteners acesulfame potassium and sucralose decreased the function of P-glycoprotein (PGP), which is also known as multidrug resistance protein 1 in the study (MDR1). PGP is a member of a family of transporters that work together to rid the body of toxins, drugs, and drug metabolites by transporting them to the liver.
“We discovered that sweeteners had an impact on PGP activity in liver cells at concentrations that were expected to be found in common foods and beverages, and that these concentrations were far below the FDA’s recommended maximum limits,” said Stephanie Olivier Van Stichelen, PhD, who is the team’s leader.
“To the best of our knowledge, we are the first group to identify the molecular mechanism by which non-nutritive sweeteners influence detoxification in the liver.” artificial sweeteners
The experiments also revealed that the sweeteners stimulate transport activity and are likely to bind to PGP, causing them to compete with and inhibit the transport of other substrates, such as xenobiotics, drugs and their metabolites, short-chain lipids, and bile acids, in the gastrointestinal tract.
Despite the fact that the findings are preliminary and need to be confirmed in further preclinical and clinical studies, the findings suggest that non-nutritive sweeteners may be problematic for people who take medications that use PGP as a primary detoxification transporter, according to the researchers. Some of these medications include antidepressants, antibiotics, and blood pressure meds..
According to Danner, “If future research demonstrate that non-nutritive sweeteners affect the body’s detoxification mechanism, it will be critical to investigate the potential interactions and determine safe amounts of consumption for at-risk groups.” There may also be value in including particular amounts of non-nutritive sweeteners on product labels so that people can keep track of their intake more easily.